NFL prop bets Week 10 2025
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NFL DFS: Optimizer reveals Week 10, 2025 daily Fantasy football picks for DraftKings, FanDuel
Now, SportsLine's NFL DFS Optimizer has turned its attention to Sunday's 2025 NFL Week 10 schedule and just locked in its top daily Fantasy football lineups. You can only see its optimal lineups at SportsLine. New users can get $50 in Pick6 credits at DraftKings when they play $5.
Discover the best NFL Week 9 parlay picks and the top sportsbook promos available right now! Get the best insights from our NFL betting experts for this week’s games.
Rams (-4.5) at 49ers: The 49ers are now without Fred Warner, Nick Bosa, and rookie 11th overall pick Mykel Williams for the season. Meanwhile, the Rams are extremely healthy for a Week 10 game. It doesn't matter to me whether Brock Purdy or Mac Jones starts. The Rams are a much better team either way.
All odds referenced are courtesy of BetMGM as of publish time.
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NFL Week 10 picks: Why we're backing Drake Maye's Patriots and several other road teams this weekend
With C.J. Stroud ruled out with a concussion, the Texans will turn to Davis Mills in Week 10. While Stroud's absence obviously lowers Houston's ceiling, I still like the Texans in this spot. Mills is a capable backup, and this matchup is more about fading Jacksonville than anything else.
The Seahawks beat the Cardinals 23-20 in Week 4 in Arizona on a last-second field goal, covering the 1.5-point spread as favorites with the Under (44) cashing. Seattle leads the all-time series 30-22-1 and has won 8 straight meetings.
NFL Week 10 picks, predictions, win probabilities for Raiders-Broncos, Falcons-Colts, Jaguars-Dolphins, Browns-Jets, Cardinals-Seahawks, more games.
Get Athlon Sports’ expert NFL picks, predictions and betting advice for every Week 10 game, including a critical Monday night NFC showdown between the Eagles and Packers.
Breaking down the Lions and Commanders before their Week 10 clash: offense, defense, and how each team’s numbers tell the story of their season.
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