A research team has uncovered and rebuilt a previously elusive plant pathway that produces oxindole alkaloids—a rare and ...

Benzylisoquinoline alkaloids (BIAs) represent a diverse group of plant secondary metabolites that are of profound pharmacological importance. These compounds, which include opiates, antimicrobial ...

Plants in the genus Tripterygium, historically utilized in traditional medicine and agriculture across East Asia, have been applied for pest control as well as for curing diseases such as rheumatoid ...

Making chemical handles that latch onto amino acids is a strategy used to make covalent drugs, antibody-drug conjugates, and biochemical probes. Cysteine and lysine are common points of attachment, ...

The elucidation of the biosynthetic pathway of ipecacuanha alkaloids shows how two distantly related plant species could develop the same substance independently Plants produce an enormous abundance ...

Alkaloids are natural nitrogen-containing compounds produced by plants and microbes. These molecules, such as morphine and quinine, are important human medicines. Alkaloids are typically polycyclic in ...

Plants make substances called alkaloids to protect themselves, and humans have long taken advantage of these chemicals, using ...

An international team of researchers has demonstrated that genetically engineered yeast cells can produce the natural plant product alstonine, which has shown positive effects in treating ...

Scientists have uncovered an unexpected way plants make powerful chemicals, revealing hidden biological connections that could transform how medicines are discovered and produced. Plants produce ...

A research team presents an overview of recent advances in the microbial biosynthesis of L-tryptophan (L-Trp) and its ...

Tetrahydropapaverine (THP) and papaverine are plant natural products with clinically significant roles. THP is a precursor in the production of the drugs atracurium and cisatracurium, and papaverine ...