In just a few decades, DNA sequencing technologies evolved from slow, manual processes to rapid, automated ones, making ...

Due to its high accuracy and fast, simple workflow, capillary electrophoresis (CE) is a foundational technology for clinical applications. CE is an invaluable tool used to detect genetic variations ...

In a way, sequencing DNA is very simple: There's a molecule, you look at it, and you write down what you find. You'd think it would be easy—and, for any one letter in the sequence, it is. The problem ...

Cellular DNA is constantly subjected to threats, both from the environment via exposure to radiation or chemicals and as a consequence of natural cellular processes, e.g., the production of endogenous ...

Despite the advent of “methylomic” analyses, bisulfite modification of genomic DNA followed by Sanger sequencing remains the most precise assay for investigating the methylation profile of specific ...