Seattle and Arizona played a thriller the last time they met back in Week 4 in a Thursday Night Football matchup.

The 2025 NFL season is past the halfway point and a bunch of big games are on tap for Week 10, led by Buccaneers vs. Patriots and Eagles vs. Packers.

Now, SportsLine's NFL DFS Optimizer has turned its attention to Sunday's 2025 NFL Week 10 schedule and just locked in its top daily Fantasy football lineups. You can only see its optimal lineups at SportsLine. New users can get $50 in Pick6 credits at DraftKings when they play $5.

NFL Week 10 best/worst quarterback, running back, tight end and wide receiver matchups for your fantasy football team.

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NFL Week 10 picks, predictions for games this week, including Bills-Dolphins, Ravens-Vikings, Lions-Commanders, Steelers-Chargers, Eagles-Packers.

Lamar Jackson looks to continue the Ravens' second-half push against the Vikings. Here's how you can watch the game.

So far, the betting odds agree that this should be a close and competitive game. DraftKings Sportsbook has the Patriots as 2.5-point underdogs with the over/under set at 48.5 points. There are plenty of interesting subplots heading into this game,