IN 1962, when David R. Davies was in his 30s, he and two coworkers at the National Institutes of Health proposed that short, guanine-rich stretches of DNA could assume unusual structures. On the basis ...
G-quadruplexes are non-canonical secondary structures formed by guanine-rich sequences in DNA and RNA. Four guanines assemble into a planar tetrad through Hoogsteen hydrogen bonding, and stacked ...
Northwestern Medicine scientists have discovered that little-studied DNA structures play a central role in organizing the human genome and controlling gene activity, according to a new study published ...
There is no more iconic image in biology than that of DNA's double-stranded helix, which coils and supercoils on itself to form dense chromosomes. But a quite different, square-shaped type of DNA ...
This image is based on an x-ray crystal structure of a G-quadruplex formed from the DNA sequence found in human genomes. This image is based on an x-ray crystal structure of a G-quadruplex formed from ...
Designers of cancer drugs have begun to aim their arrows at an up-and-coming series of targets in the human genome: quadruplexes, a family of DNA structures that form in sites that switch genes on ...
DNA, the genetic material compacted in chromosomes, stores information to regulate all the cell processes in the body. Two decades ago, in addition to the widely known Watson-Crick double helix model ...
Most women with ovarian cancer respond very well to chemotherapy at first – but in 70% of cases the cancer grows back. And although many patients will respond to chemotherapy a second or third time, ...
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