ALZFORUM

‛iNET’ Cultures Expose NPTX2 as TDP-43 Henchman

The pathological accumulation of TDP-43 that underlies many cases of FTD, ALS, and LATE-NC has been notoriously difficult to recapitulate in mice or cultured human cells. In a paper published February ...
Medical Xpress

Protein 'seeds' trigger key pathological features of ALS and frontotemporal dementia

Accumulation of a protein called TDP-43 is a key feature of ALS and frontotemporal dementia. In a study published in Neuron, researchers report 'seeding' this accumulation through fragments of the ...
ALZFORUM

Sans Nuclear TDP-43, Splicing of An ALS/FTD Gene Goes Awry

In amyotrophic lateral sclerosis and frontotemporal dementia, loss of the RNA-binding protein TDP-43 from the nucleus creates a surge of mis-spliced mRNAs in neurons. So far, only one of these errant ...
Medical Xpress

New insight into how protein TDP-43 affects gene expression in ALS and FTD

Neurodegenerative diseases, such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are medical conditions characterized by the progressive degradation ...