That being said, here's a look at four players the Bills could target as potential replacements at the NFL trade deadline. Buffalo could decide to go with a true defensive tackle, which would not only help replace Hoecht, but also Ed Oliver as well. That's why Sebastian Joseph-Day is someone to keep an eye on.

Making his first start in Week 8, the Buffalo Bills finally saw what defensive end Michael Hoecht brings to the team. And what a start it was. Now the question is if he can keep bringing similar heat in Week 9 against quarterback Patrick Mahomes and the Kansas City Chiefs.

Joey Bosa calls Hoecht's injury a "massive loss" to Buffalo's defense that had pressured Patrick Mahomes on 52% of his dropbacks in Sunday's win.

Sean McDermott and the Buffalo Bills pulled off a big win on Sunday, taking down the Kansas City Chiefs, 28-21. Unfortunately for Buffalo, the victory came at a substantial cost, with defensive tackle Miachael Hoecht suffering a non-contact foot injury during the game.

Buffalo Bills defensive ends Michael Hoecht and Greg Rousseau combine to sack Kansas City Chiefs quarterback Patrick Mahomes on third down for a nine-yard loss.

It was what he did after the whistle that could land him in trouble with the NFL. Hoecht was penalized for unnecessary roughness on Carolina’s first play of their final drive. The NFL reviews all plays and will fine players for unnecessary roughness plays, whether they were called for a penalty during the game.