The San Francisco 49ers suffered their worst loss of the 2025 NFL season in Week 8, falling 26-15 to the Houston Texans on the road. The offense struggled, mana

Kickoff from NRG Stadium is set for 1 p.m. ET, and the Texans are 2.5-point favorites, according to the latest 49ers vs. Texans odds. The over/under for total points scored is 42. The Texans are -151 money line favorites (risk $151 to win $100),

Highlights from the Week 8 matchup between the San Francisco 49ers and the Houston Texans during the 2025 NFL season.

The San Francisco 49ers will face the Houston Texans in Week 8 of the NFL season on Sunday at NRG Stadium.

The San Francisco 49ers got Alfred Collins back late in the second quarter against the Texans and almost immediately lost another defensive lineman.

The Texans have dominated the 49ers, outgaining them 230 to 25 and outscoring them 13-0. The Texans have 10 first downs to none for the 49ers, who had only four plays in the first quarter with Christian McCaffrey getting no touches.

The Texans arguably played one of their better games of the season and Houston's Week 8 report card reflects that.

Purdy was on the 49ers’ sideline in a road game for the first time since re-aggravating his toe injury against the Jaguars. He did not travel to Los Angeles on Oct. 2, and didn't travel to Tampa on Oct. 11. While he was on the sideline for last week’s game against Atlanta, that was a home game.

The Texans beat the 49ers 26-15, and it wasn’t that close. Houston has won three of four to improve to 3-4, while San Francisco fell to 5-3. The Texans outgained the 49ers 475 to 223, had 31 more plays, 11 more first downs and won the time of possessions 41:22 to 18:38. The Texans did not punt until 4:13 remained.