More than 40 methyl transfers from SAM are known, to various substrates such as nucleic acids, proteins, lipids and secondary metabolites. It is made from adenosine triphosphate (ATP) and …

Aug 13, 2025 · The supplement might increase anxiety and mania. If you have a compromised immune system, talk to your doctor before taking SAMe. People who have a weakened immune system may …

This fact sheet provides basic information about SAMe (S-adenosyl-L-methionine), summarizes research on safety and effectiveness, and suggests sources for additional information.

Aug 11, 2025 · What is s-adenosylmethionine (SAMe)? S-adenosylmethionine (also known as SAMe) is a man-made form of a chemical that occurs naturally in the body. SAMe is likely effective in …

Jun 20, 2025 · A lab-made form of SAM-e is sold as a supplement in the U.S., but SAM-e has been sold as a prescription drug in parts of Europe for decades. Its scientific name is S-adenosylmethionine.

Jul 2, 2025 · S-Adenosyl-L-methionine (SAMe) is a derivative of methionine and a cofactor for multiple synthetic pathways, particularly as a methyl group donor. It is produced naturally in the body, mainly …

Sep 3, 2025 · S-adenosylmethionine (SAMe) is a metabolite in the body that helps maintain several important biological reactions.

Nov 1, 2002 · In this symposium, experts presented an up-to-date review of the molecular and biological aspects of S-adenosylmethionine (SAMe), especially as these pertain to pathology in the main …

S -Adenosyl- l -methionine (SAM) is a naturally occurring trialkyl sulfonium molecule that is typically associated with biological methyltransfer reactions. However, SAM is also known to donate …

SAMe is a molecule that is made naturally in the body from homocysteine and folate. It can also be made in a lab and taken in supplements. SAMe is involved in the formation, activation, and...