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Do you challenge PCN allergies? The PEN-FAST-ED study demonstrated that pharmacist-led direct beta-lactam rechallenge in the emergency department is safe and effective for patients with low-risk penicillin allergies. This single-center, prospective observational study conducted from October 2023 to March 2024 enrolled 100 adult ED patients with documented penicillin allergies who had orders for non-beta-lactam antibiotics. Pharmacists used the PEN-FAST clinical decision tool to risk-stratify pat
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